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The ACS recommends that screening for (1) breast cancer begins at age 20 and includes mammography from age 40 (at least annually), (2) cervical cancer begins no later than age 21 (Pap test), (3) colorectal cancer begins at age 50 (several options), and (4) prostate cancer begins at age 50 (prostate-specific antigen test and digital rectal examination annually) (Table 3). Once the base is removed, the apurinic/apyrimidinic (AP)-site is removed by an AP-endonuclease or an AP-lyase, which cleave the DNA strand 5′ or 3′ to the AP-site respectively. He noted that genomic analysis from the Human Microbiome Project has identified two bacterial species (one from the gut, the other on skin) with natural product gene clusters similar to those known to express a venerable class of antibiotics known as thiopeptides. Prolonged duration of illness has been demonstrated in four case-control studies of fluoroquinolone-resistant Campylobacter.

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